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Frontiers of Agricultural Science and Engineering >> 2019, Volume 6, Issue 1 doi: 10.15302/J-FASE-2018222

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

1. College of Veterinary Medicine/Shaanxi Centre of Stem Cells Engineering and Technology, Northwest A&F University, Yangling 712100, China
2. Centre for Healthy Brain Ageing, UNSW Medicine, Randwick NSW 2031, Australia

Accepted: 2018-05-16 Available online: 2019-02-25

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Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogonia or oocytes. However, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cells and then by reprogramming to induce them to become pluripotent stem cells (iPSCs). These two stages can be completely implemented with mouse cells. However, authentic porcine iPSCs have not been established. Here, we discuss recent advances in the stem cell field for obtaining iPSCs from PGCs. This knowledge will provide some clues which will contribute to the regulation of reprogramming to pluripotency in farm species.

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