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Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 277-281 doi: 10.15302/J-FASE-2014036

Abstract: Vaccination for highly pathogenic avian influenza (HPAI) has been implemented in China for a decade,

Keywords： highly pathogenic avian influenza     vaccine     vaccination     control    

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Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 188-196 doi: 10.15302/J-FASE-2019253

Abstract:

Microneme proteins (MICs) are important for Apicomplexan parasite invasion due to their adhesion to host cells. Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccine candidates against neosporosis. In this study, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3 and NcMIC8. BALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, and challenged with tachyzoites. The immune responses were evaluated through cytokine, antibody measurements and the parasite burden in the mice brain tissues. Serological analysis showed that recombinant protein vaccines induced higher levels of immunoglobulin G (IgG) than other groups. The percentage of IgG1 and IgG2a in the recombinant protein groups was higher than the other groups, and with a predominance of IgG1 over IgG2a, suggesting that recombinant protein vaccines elicited a Th2-type immune response, while DNA vaccines mainly produce a Th1-type immune response. In addition, mice immunized with rNcMIC3 and rNcMIC8 a had lower parasite burden in brain tissue compared with the other groups. These results demonstrate that rNcMIC3 and rNcMIC8 could induce humoral and Th2-type immune response, leading to a considerable level of resistance against neosporosis.

Keywords： NcMIC3     NcMIC8     Neospora caninum     vaccination    

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Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 562-575 doi: 10.1007/s11684-022-0977-3

Abstract: rate against severe/critical disease in the 4854 cases in our BA.2.2 patient cohort with traceable vaccinationFurthermore, even though age was a critical risk factor of the severity of COVID-19 post BA.2.2 infection, vaccination-elicited

Keywords： SARS-CoV-2     COVID-19     host response     bronchoalveolar lavage fluid (BALF)    

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Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 747-757 doi: 10.1007/s11684-022-0954-x

Abstract: convalescents susceptible to re-infection and have raised concern about the efficacy of inactivated vaccinationThey were classified into three groups (no-vaccination (n = 54), one-dose (n = 62), andtwo-dose (n = 92) groups) on the basis of the administration of inactivated vaccination.The neutralizing antibody (NAb) titers against the wild-type virus continued to decrease in the no-vaccinationThe NAb titers against the Delta variant for the no-vaccination, one-dose, and two-dose groups decreased

Keywords： COVID-19 convalescent     SARS-CoV-2     inactivated vaccination     neutralizing antibody     B cell response    

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Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke

Frontiers of Medicine 2023, Volume 17, Issue 6,   Pages 1047-1067 doi: 10.1007/s11684-023-1041-7

Abstract: The coronavirus disease 2019 (COVID-19) epidemic has triggered a huge impact on healthcare, socioeconomics, and other aspects of the world over the past three years. An increasing number of studies have identified a complex relationship between COVID-19 and stroke, although active measures are being implemented to prevent disease transmission. Severe COVID-19 may be associated with an increased risk of stroke and increase the rates of disability and mortality, posing a serious challenge to acute stroke diagnosis, treatment, and care. This review aims to provide an update on the influence of COVID-19 itself or vaccines on stroke, including arterial stroke (ischemic stroke and hemorrhagic stroke) and venous stroke (cerebral venous thrombosis). Additionally, the neurovascular mechanisms involved in SARS-CoV-2 infection and the clinical characteristics of stroke in the COVID-19 setting are presented. Evidence on vaccinations, potential therapeutic approaches, and effective strategies for stroke management has been highlighted.

Keywords： SARS-CoV-2     ischemic stroke     stroke     hemorrhagic stroke     cerebral venous thrombosis     vaccination    

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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 185-195 doi: 10.1007/s11684-021-0913-y

Abstract: Vaccination strategies need to adapt to these challenges to keep population immunity above the herd immunity

Keywords： COVID-19     pandemics     SARS-CoV-2     vaccination    

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Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 938-941 doi: 10.1007/s11684-021-0895-9

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tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette--Guérin booster vaccination

Hengjing Li, Henan Xin, Shukun Qian, Xiangwei Li, Haoran Zhang, Mufei Li, Boxuan Feng, Qi Jin, Lei Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 528-535 doi: 10.1007/s11684-017-0573-0

Abstract: infection among adolescents born after terminating the Bacillus Calmette–Guérin (BCG) booster vaccinationskin testing (TST) and QuantiFERON-TB Gold assay (QFT) to investigate the influence of neonatal BCG vaccinationOnly TST was positively associated with BCG vaccination with an adjusted odds ratio of 1.71 [95% confidenceOur results suggested that BCG neonatal vaccination still affects TST performance, and a two-step approach

Keywords： tuberculin skin test     interferon-γ release assays     adolescent     agreement    

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: Over the last seven decades, vaccination strategies have been utilized to protect people from complicationsWhile current vaccination regimens elicit strain-specific antibody responses, they fail to generate cross-protectioninfluenza and linking innate and adaptive immune mechanisms, thus making them attractive targets for vaccination

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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The East–West Divide in Response to COVID-19 Article

Dean T Jamison, Kin Bing Wu

Engineering 2021, Volume 7, Issue 7,   Pages 936-947 doi: 10.1016/j.eng.2021.05.008

Abstract:

Coronavirus disease 2019 (COVID-19) deaths per million population in the countries of the West had often exceeded those in the countries of the East by factor of 100 by May 2021. In this paper, we refer to the West as represented by the United States plus the five most populous countries of Western Europe (France, Germany, Italy, Spain, and the United Kingdom), and the East as the 15 countries in East Asia and Oceania that are members of the Regional Comprehensive Economic Partnership, RCEP (Australia, Brunei, Cambodia, China, Indonesia, Japan, the Republic of Korea, Laos, Malaysia, Myanmar, New Zealand, Philippines, Singapore, Thailand, and Vietnam). This paper argues that currently available information points to the factors most responsible for the East–West divide. Warnings by early January
2020 about an atypical viral pneumonia in Wuhan, China, prompted rapid responses in many jurisdictions in East Asia. Publication of the virus’s genome on 10 January 2020 provided essential information for making diagnostic tests and launching vaccine development. China’s lockdown of Wuhan on 23 January 2020 provided a final, decisive signal of the danger of the new disease. By late March 2020, China had fully controlled its epidemic, and many other RCEP countries had taken early and decisive measures, including restrictions on travel, that aborted serious outcomes. Inaction during the critical month of February 2020 in the United States and most other Western countries allowed the disease to take hold and spread. In both the East and the West, stringent population-wide non-pharmaceutical interventions were widely implemented at great cost to societies, economies, and school systems. Without these measures, the outcomes could have been even worse. Most countries in the East also implemented tightly focused policies to isolate infectious individuals. Even today, most countries in the West allow infectious individuals to mingle with their families, coworkers, and communities. Much of the East–West divide plausibly results from failure in the West to implement the basic public health policies of early action and the isolation of infectious individuals. Widespread immunization in some RCEP and high-income countries will soon attenuate their outbreaks, while the slow rollout of vaccines in lower income countries is replacing the East–West divide in outcomes with a North–South one. The South is thus replacing the West as the breeding ground for more dangerous variants as exemplified by the highly contagious Delta variant, which may undermine hitherto successful control strategies in many countries.

Keywords： Coronavirus disease 2019     Isolation     Non-pharmaceutical interventions     Pandemic     Vaccination    

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A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China Article

Ting Zhang, Qing Wang, Zhiwei Leng, Yuan Yang, Jin Yang, Fangyuan Chen, Mengmeng Jia, Xingxing Zhang, Weiran Qi, Yunshao Xu, Siya Chen, Peixi Dai, Libing Ma, Luzhao Feng, Weizhong Yang

Engineering 2021, Volume 7, Issue 7,   Pages 948-957 doi: 10.1016/j.eng.2021.03.020

Abstract: We found that, under strict non-pharmaceutical interventions (NPIs) or mass vaccination of the population

Keywords： COVID-19     Transmission dynamics model     Clinical resource demands     Vaccination    

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Title Author Date Type Operation

Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

Journal Article

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Journal Article

Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak

Journal Article

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Journal Article

Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke

Journal Article

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Journal Article

Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination

Journal Article

tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette--Guérin booster vaccination

Hengjing Li, Henan Xin, Shukun Qian, Xiangwei Li, Haoran Zhang, Mufei Li, Boxuan Feng, Qi Jin, Lei Gao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

The East–West Divide in Response to COVID-19

Dean T Jamison, Kin Bing Wu

Journal Article

A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China

Ting Zhang, Qing Wang, Zhiwei Leng, Yuan Yang, Jin Yang, Fangyuan Chen, Mengmeng Jia, Xingxing Zhang, Weiran Qi, Yunshao Xu, Siya Chen, Peixi Dai, Libing Ma, Luzhao Feng, Weizhong Yang

Journal Article