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Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women

Qiu Yi,Wang Leiguang and Yu Ling

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 39-46

Abstract:

This study aimed at exploring a new 3-dimensional reticular intrauterine device (3-DR-IUD) composed of nitinol and silicone rubber and observing the contraceptive efficacy and side effects of the device in reproductive women. The frame of the 3-DR-IUD was constructed with silicone rubber and nitinol wire. The 3-DR-IUD was placed into uterus in an outpatient procedure. One hundred and fifty- two women were divided equally into the 3-DR-IUD group (n=76) and the 2- dimensional intrauterine device (2- D- IUD) group (n=76，control group). Patient follow-ups were performed in 1～12 months post-operation. The side effects of intrauterine device (IUD)，such as abnormal leucorrhea，menstrual flow changes in uterine bleeding profusely and pain，etc，were investigated. The pregnancy rate，expulsion rate，removal rate of IUD for medical reasons and the continuation rate were evaluated. The ultrasound and pelvic X-ray were carried out to examine IUDs. The results showed that two groups with 76 cases of each successfully placed IUD and there were no severe pain during the operation. The incidence of lumbago/abdominal pain and the occurrence of leucorrhea and irregular vaginal bleeding in the 3-DR-IUD group (7.9 %，6/76) were significantly lower than that of the 2-DIUD group (40.8 %，31/76) during the first 12 months for use of IUD (P<0.000 1). The pregnancy rate，expulsion rate and take-off rate due to symptom were 0 %，0 % and 1.3 % in 3-DRIUD group，respectively，and 1 of 76 woman take-off 3-DR-IUD was due to allergy for silicon rubber. The continuation rate was 98.7 % (75/76) in the 3-DR-IUD group，comparing with the 2-D-IUD group (86.8 % ，66/76)，the difference was significantly (P=0.009). Therefore，the 3-DR-IUD demonstrates long-term patient tolerability，satisfaction and efficacy as a contraceptive.The 3-DR-IUD appears to be a new，safe and effective devise of contraception.

Keywords： 3-DR-IUD     clinical trials     side effects     contraceptive efficacy    

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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinicalinsufficient biomarkers for prognosis/efficacy, and inability to identify potential novel therapies in clinicaltrials., we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical

Keywords： rare tumors     diagnosis flowchart     treatment strategy     clinical trials recommendation    

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Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 333-335 doi: 10.1007/s11684-011-0166-2

Abstract: Cell therapy holds promise in addressing a number of unmet medical needs but despite its considerable impetus, faces numerous challenges including support for translational research in this area. Here, we examine the challenges confronting cell therapy research including the limited funding available for translational research partly due to the uncompetitive nature of required validation studies in cell therapy that of necessity are not hypothesis-driven. Other issues include lack of standardization of definitions of cell products, uncertainty regarding optimum preclinical animal models, duplication of efforts to secure regulatory approval and a lack of uniformity of nomenclature for some cell products. Nonetheless, several initiatives to address all of these issues are underway.

Keywords： stem cells     clinical trials     funding     animal models     standardization     common definitions    

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Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 736-744 doi: 10.1007/s11684-021-0870-5

Abstract: A pilot study on TCM syndrome differentiation can evaluate the clinical efficacy and safety of TCM andlay a foundation for further clinical research.

Keywords： pneumoconiosis     randomized controlled trials     traditional Chinese medicine    

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Next Steps for Efficacy Evaluation in Clinical Trials of COVID-19 Vaccines

Hu-Dachuan Jiang, Li Zhang, Jing-Xin Li, Feng-Cai Zhu

Engineering 2021, Volume 7, Issue 7,   Pages 903-907 doi: 10.1016/j.eng.2021.04.013

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targetedPUBMED and EMBASE databases were searched for eligible trials.ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials    

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Consolidated standards of reporting trials (CONSORT) for traditional Chinese medicine: current situation

Zhaoxiang Bian, Baoyan Liu, David Moher, Taixiang Wu, Youping Li, Hongcai Shang, Chungwah Cheng

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 171-177 doi: 10.1007/s11684-011-0132-z

Abstract: The reporting standards for randomized controlled trials were first published in 1996 by a group of scientistsunder the name “CONSORT,” which means consolidated standards of reporting trials.

Keywords： CONSORT for TCM     reporting standards     future development    

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Three-dimensional conformal and intensity modulated radiation therapy for hepatocellular carcinoma:basic study and clinicaltrials

Jiang Guoliang

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 129-136

Abstract:

This report consists of two parts: basic study and clinical trial forAnd 3 clinical trials have been carried out, which yielded encouraging outcome with 3-year rvivals oftechnique of HCC irradiation,which is fit to Chinese HCC,has been successfully applied in a series of clinicaltrials.It demonstrates that radiation therapy is one of the treatment choices for medically inoperable

Keywords： 3-dimensional conformal radiation therapy     intensity modulated radiation therapy     epatocellular carcinoma     liver irradiation tolerance    

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Current State of Monoclonal Antibody Therapy for Allergic Diseases Review

Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying

Engineering 2021, Volume 7, Issue 11,   Pages 1552-1556 doi: 10.1016/j.eng.2020.06.029

Abstract: the cytokines and immunoglobulin involved in the development of allergic diseases, and to discuss the clinical

Keywords： Allergic disease     Monoclonal antibody     Anti-IgE     Cytokines     Clinical trials    

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Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues Review

Yonghong Li, Yan Huo, Lei Yu, Junzhi Wang

Engineering 2019, Volume 5, Issue 1,   Pages 122-131 doi: 10.1016/j.eng.2018.12.003

Abstract: At present, exciting results are being achieved in clinical applications of CAR-T cells for patients

Keywords： Chimeric antigen receptor T cells     Quality control     Nonclinical research     Safety     Efficacy     Clinicaltrials     Cancer immunotherapy    

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A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 259-263 doi: 10.1007/s11684-008-0049-3

Abstract: All available published data of randomized clinical trials comparing transurethral resection plus intravesical
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Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) Article

Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang

Engineering 2020, Volume 6, Issue 10,   Pages 1147-1152 doi: 10.1016/j.eng.2020.03.002

Abstract:

Since its outbreak in December 2019, a series of clinical trials on coronavirus disease 2019 (COVIDHowever, the significant heterogeneity and less critical outcomes of such trials may be leading to aThis study aimed to develop a core outcome set (COS) for clinical trials on COVID-19 in order to tackleThe study was conducted according to the Core Outcome Measures in Effectiveness Trials (COMET) Handbookclassifications of COVID-19 were identified and determined to constitute the COS for clinical trials

Keywords： Novel coronavirus pneumonia     Core outcome set     COVID-19     2019-nCoV     Coronavirus disease     Clinical trials    

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Evolution of partnering contracts — new engineering contract trials

Liu Zhengguang

Strategic Study of CAE 2012, Volume 14, Issue 12,   Pages 81-84

Abstract:

With the development of society, the engineering industry has become very complex, so the traditional construction contract can not meet the requirement of increasingly diversified development of enginee-ring. Therefore, through wide study and discussion, the Institution of Civil Engineers (ICE) agreed to improve the construction contract. In 1993, the new engineering contract (NEC) was launched by ICE to encourage the “team spirit” and establish a good partnership. After nearly 20 years of application, it was proved very effective. In 2009, the Hong Kong Special Administrative Region Government introduced NEC tentatively. The experience of the first project using NEC was introduced in the paper. The project results show that the NEC can save the duration and cost, reduce the contract disputes and increase effectiveness, which enhances the confidence of the engineering industry for introducing NEC.

Keywords： traditional engineering contract     NEC     experience of NEC    

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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology     traditional Chinese medicine     clinical terminology    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Title Author Date Type Operation

Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women

Qiu Yi,Wang Leiguang and Yu Ling

Journal Article

Rare tumors: a blue ocean of investigation

Journal Article

Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Journal Article

Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients

Journal Article

Next Steps for Efficacy Evaluation in Clinical Trials of COVID-19 Vaccines

Hu-Dachuan Jiang, Li Zhang, Jing-Xin Li, Feng-Cai Zhu

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article

Consolidated standards of reporting trials (CONSORT) for traditional Chinese medicine: current situation

Zhaoxiang Bian, Baoyan Liu, David Moher, Taixiang Wu, Youping Li, Hongcai Shang, Chungwah Cheng

Journal Article

Three-dimensional conformal and intensity modulated radiation therapy for hepatocellular carcinoma:basic study and clinicaltrials

Jiang Guoliang

Journal Article

Current State of Monoclonal Antibody Therapy for Allergic Diseases

Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying

Journal Article

Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues

Yonghong Li, Yan Huo, Lei Yu, Junzhi Wang

Journal Article

A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Journal Article

Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)

Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang

Journal Article

Evolution of partnering contracts — new engineering contract trials

Liu Zhengguang

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article