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Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine Review
Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yujie Li, Fulong Liao, Tingliang Jiang,Youyou Tu
Engineering 2019, Volume 5, Issue 1, Pages 32-39 doi: 10.1016/j.eng.2018.11.011
Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and understanding this remarkable phytochemical and its unique chemical and pharmacological properties. Today, even as artemisinin continues to serve as the foundation for antimalarial therapy, numerous challenges have surfaced in the continued application and development of this family of drugs. These challenges include the emergence of delayed treatment responses to artemisinins in malaria and efforts to apply artemisinins for non-malarial indications. Here, we provide an overview of the story of artemisinin in terms of its past, present, and future. In particular, we comment on the current understanding of the mechanism of action (MOA) of artemisinins, and emphasize the importance of relating mechanistic studies to therapeutic outcomes, both in malarial and non-malarial contexts.
Keywords: Artemisinin Mechanism of action Malaria Anti-cancer
Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia
Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 130-138 doi: 10.1007/s11684-017-0555-2
Keywords: brown adipose tissue beige adipocyte anti-obesity anti-diabetes cancer cachexia aging
Curcumin based combination therapy for anti-breast cancer: from
Sunhui Chen,Qiuling Liang,Shuping Xie,Ergang Liu,Zhili Yu,Lu Sun,Meong Cheol Shin,Seung Jin Lee,Huining He,Victor C. Yang
Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 3, Pages 383-388 doi: 10.1007/s11705-016-1574-2
Keywords: curcumin sunitinib synergistic effect bovine serum albumin (BSA) nano-carriers
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 105-118 doi: 10.1007/s11684-022-0934-1
Keywords: osimertinib anti-CD47 antibody combination strategy ADCP EGFR
Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2, Pages 306-332 doi: 10.15302/J-FASE-2023488
● Using visual analysis to predict the trend of natural product pest resistance.
Keywords: anti-pest activity crop protection insect pest natural product visual analysis
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 729-746 doi: 10.1007/s11684-022-0978-2
Keywords: hepatocellular carcinoma YAP1 Akkermansia muciniphila anti-PD-1 dihydroartemisinin bile acid
A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables
Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0722-2
Keywords: modular robotic arm anti-parallelogram mechanism Bowden cable humanoid arm lightweight joint design
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 942-942 doi: 10.1007/s11684-021-0876-z
Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12, Pages 1866-1878 doi: 10.1007/s11705-023-2340-x
Keywords: implantable glucose biosensor anti-biofouling continuous glucose monitoring immune responses
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7, Pages 966-975 doi: 10.1007/s11705-022-2244-1
Keywords: alkali lignin red light carbon dots hypochlorite encryption and anti-counterfeiting
SUN Mingxiao, WANG Yao, CHI Jiamin
Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 174-177 doi: 10.1007/s11684-008-0032-z
Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1497-0
• Nanoparticle incorporation and anti-biofouling grafting were integrated
Keywords: Anti-biofouling grafting Nanoparticle incorporation Sterilization rates Water flux Water flux recovery
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Frontiers of Medicine doi: 10.1007/s11684-023-1037-3
Keywords: COVID-19 antiviral drugs mindeudesivir
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea
Keywords: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Mobile CRISPR-Cas9 based anti-phage system in E. coli
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8, Pages 1281-1289 doi: 10.1007/s11705-022-2141-7
Keywords: phage infections anti-phage CRISPR-Cas9 conjugative transfer synthetic biology
Title Author Date Type Operation
Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine
Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yujie Li, Fulong Liao, Tingliang Jiang,Youyou Tu
Journal Article
Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia
Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee
Journal Article
Curcumin based combination therapy for anti-breast cancer: from
Sunhui Chen,Qiuling Liang,Shuping Xie,Ergang Liu,Zhili Yu,Lu Sun,Meong Cheol Shin,Seung Jin Lee,Huining He,Victor C. Yang
Journal Article
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer
Journal Article
QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE
Journal Article
Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD
Journal Article
A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables
Journal Article
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer
Journal Article
Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems
Journal Article
Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting
Journal Article
Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes
SUN Mingxiao, WANG Yao, CHI Jiamin
Journal Article
Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for
Journal Article
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Journal Article
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen
Journal Article