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Management innovation of Chang’e-5 project

Frontiers of Engineering Management 2021, Volume 8, Issue 4,   Pages 620-626 doi: 10.1007/s42524-021-0165-1

Keywords： lunar exploration     sample return     systems engineering     project management    

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Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 1,   Pages 1-14 doi: 10.1007/s11705-015-1509-3

Abstract: With the development of modern technology like high throughput screening, combinatorial chemistry and computer aid drug design, the drug discovery process has been dramatically accelerated. However, new drug candidates often exhibit poor aqueous or even organic medium solubility. Additionally, many of them may have low dissolution velocity and low oral bioavailability. Nanocrystal formulation sheds new light on advanced drug development. Due to small (nano- or micro- meters) sizes, the increased surface-volume ratio leads to dramatically enhanced drug dissolution velocity and saturation solubility. The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer). In addition to the comprehensive review of different technologies and methods in drug nanocrystal preparation, suspension, and stabilization, we will also compare nano- and micro-sized drug crystals in pharmaceutical applications and discuss current nanocrystal drugs on the market and their limitations.

Keywords： drug nanocrystal     nanotechnology     formulation     bioavailability     stabilizers     drug delivery    

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Using heterogeneous patent network features to rank and discover influential inventors

Yong-ping DU,Chang-qing YAO,Nan LI

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 7,   Pages 568-578 doi: 10.1631/FITEE.1400394

Abstract: Most classic network entity sorting algorithms are implemented in a homogeneous network, and they are not applicable to a heterogeneous network. Registered patent history data denotes the innovations and the achievements in different research fields. In this paper, we present an iteration algorithm called inventor-ranking, to sort the influences of patent inventors in heterogeneous networks constructed based on their patent data. This approach is a flexible rule-based method, making full use of the features of network topology. We sort the inventors and patents by a set of rules, and the algorithm iterates continuously until it meets a certain convergence condition. We also give a detailed analysis of influential inventor’s interesting topics using a latent Dirichlet allocation (LDA) model. Compared with the traditional methods such as PageRank, our approach takes full advantage of the information in the heterogeneous network, including the relationship between inventors and the relationship between the inventor and the patent. Experimental results show that our method can effectively identify the inventors with high influence in patent data, and that it converges faster than PageRank.

Keywords： Heterogeneous patent network     Influence     Rule-based ranking    

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Implications of astrocytes in neurovascular coupling

You ZHOU MD, Chang-Kai SUN MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 43-45 doi: 10.1007/s11684-010-0019-4

Abstract: Normal brain function requires continuous supply of oxygen and glucose in a strict manner. The close spatial and temporal relationship between neural activity and cerebral blood flow (CBF) is termed as neurovascular coupling, which is dependent or not dependent on astrocytes. The increase in flow evoked by brain activity is mediated by the concerted action of multiple mediators that originate from different cells and act at different levels of the cerebral vasculature. More studies are needed for further understanding the precise mechanisms underlying neurovascular coupling, especially the implications of astrocytes.

Keywords： cerebral blood flow     neurovascular coupling     astrocyte    

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Templated synthesis of urchin-like zinc oxide particles by micro-combustion

Xintong ZHOU, Quan ZHANG, Chang-jun LIU

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 1,   Pages 73-78 doi: 10.1007/s11705-014-1404-3

Abstract: Micro-combustion initiated by dielectric barrier discharge plasma has been applied for the removal of carbon template to prepare urchin-like ZnO particles. The combustion is operated at atmospheric pressure and low gas temperature (less than 150 °C), and the template is fully decomposed and rapidly removed. The obtained urchin-like ZnO possesses two distinct morphologies: nanosheets and sub-micro rods. The unique morphologies form on ZnO hexagonal nuclei with the template effect of activated carbon.

Keywords： dielectric-barrier discharge     zinc oxide     carbon template     removal     plasma    

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Effect of different gas releasing methods on anaerobic fermentative hydrogen production in batch cultures

Sheng CHANG, Jianzheng LI, Feng LIU, Ze YU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 6,   Pages 901-906 doi: 10.1007/s11783-012-0403-1

Abstract: Decreasing hydrogen partial pressure can not only increase the activity of the hydrogen enzyme but also decrease the products inhibition, so it is an appropriate method to enhance the fermentative hydrogen production from anaerobic mixed culture. The effect of biogas release method on anaerobic fermentative hydrogen production in batch culture system was compared, i.e., Owen method with intermediately release, continuous releasing method, and continuous releasing+ CO absorbing. The experimental results showed that, at 35°C, initial pH 7.0 and glucose concentration of 10 g·L , the hydrogen production was only 28 mL when releasing gas by Owen method, while it increased two times when releasing the biogas continuously. The cumulative hydrogen production could reach 155 mL when carbon dioxide in the gas stream was continuously absorbed by 1 mol·L NaOH. The results showed that acetate was dominated, accounting for 43% in the dissolved fermentation products in Owen method, whereas the butyrate predominated and reached 47%–53% of the total liquid end products when releasing gas continuously. It is concluded that the homoacetogenesis could be suppressed when absorbing CO in the gas phase in fermentative hydrogen production system.

Keywords： batch fermentation     hydrogen production     biogas releasing     hydrogen pressure     homoacetogenesis    

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Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 461-470 doi: 10.1007/s11684-019-0695-7

Abstract: The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC). To learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRC. A total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normal group). The microbiome of the mucosal–luminal interface of each subject was sampled and analyzed using 16S rRNA gene amplicon sequencing. We also used Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) to predict microbial functional profiles. The microbial composition of the mucosal lumen differed between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectal carcinogenesis. We identified a significant reduction in which is a butyrate-producing genera of bacteria, and a significant increase in in the gut microbiota of CRC patients. Different levels of gut microflora in healthy and CRC samples were identified. The observed abundance of bacterial species belonging to and may serve as a promising biomarker for the early detection of CRC.

Keywords： colorectal cancer (CRC)     gut microbiota     intestinal     Eubacterium     Devosia    

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Preparation and characterization of a novel microorganism embedding material for simultaneous nitrification and denitrification

Ming Zeng, Ping Li, Nan Wu, Xiaofang Li, Chang Wang

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 6, doi: 10.1007/s11783-017-0961-3

Abstract: A novel microorganism embedding material was prepared to enhance the biological nitrogen removal through simultaneous nitrification and denitrification. Polyvinyl alcohol (PVA), sodium alginate (SA) and cyclodextrin (CD) were used to compose gel bead with embedded activated sludge. The effects of temperature, CD addition and concentrations of PVA and SA on nitrogen removal were evaluated. Results show that the gel bead with CD addition at 30°C contributed to the highest nitrogen removal efficiency and nitrogen removal rate of 85.4% and 2.08 mg·(L·h)?1, respectively. Meanwhile, negligible NO3? and NO2? were observed, proving the occurrence of simultaneous nitrification and denitrification. The High-Throughput Sequencing confirms that the microbial community mainly contained Comamonadaceae in the proportion of 61.3%. Overall, CD increased gel bead’s porosity and resulted in the high specific endogenous respiration rate and high nitrogen removal efficiency, which is a favorable additional agent to the traditional embedding material.

Keywords： Immobilization technology     Nitrogen removal     Cyclodextrin     Microbial community     Wastewater treatment    

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Erratum to: Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 4, doi: 10.1631/FITEE.17e0814

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Strategic Thinking on a Revolution/an Evolution in Production and Consumption of Energy in China

Ke-chang Xie,Ke Liu

Frontiers of Engineering Management 2014, Volume 1, Issue 1,   Pages 30-36 doi: 10.15302/J-FEM-2014006

Abstract: This article summarizes the thinking behind the call for a revolution/an evolution in China's energy production and consumption. China is still a developing country, though it has experienced fast economic growth in the past thirty years. It achieved great accomplishments surprising the world, and it is also confronted with challenges on energy supply and environmental protection. As environmental pollution becomes more and more serious, the energy challenges have become more and more complicated. With this in mind, the authors analyzed China's energy situation, China's energy supply and consumption, the world energy map, China's commitment both to improving its domestic environment and fulfilling its international obligations to control climate change. Action plans are presented to support the call for a revolution/an evolution in China's energy production and consumption as an effective assurance for China's ambitious goal of building a moderately prosperous society in all respects.

Keywords： revolution     evolution     energy     production     consumption    

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Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis

Lingchong WANG, Hao WU, Nian CHANG, Kun ZHANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 238-244 doi: 10.1007/s11705-010-0002-2

Abstract: Total macromolecule extract was obtained from the soft body of by the coupling techniques of decoction and alcohol precipitation. The extract was deproteinized with an ion exchange column, and resulted in the purifying of the crude polysaccharide fraction. It was found by chemical analysis that the crude polysaccharide part is composed of abundant polysaccharides (>95%) and few proteins (<1%). Furthermore, only one type of monosaccharide, glucose, was detected from its hydrolytes by thin-layer chromatography, indicating that the polysaccharides might be analogs of glucosan. The anti-hyperglycemia effects of the crude polysaccharide part were preliminarily investigated using several pharmacological methods in normal and diabetic mice. Animal experimental results showed that the crude polysaccharide fraction exhibited proper glycemia inhibition activity, and 300 mg/kg-weight dose has the optimal effect among all the studied doses. It is concluded that the crude polysaccharide fraction can be explored as a novel health product that possesses potential as an anti-hyperglycemic agent.

Keywords： anti-hyperglycemia     Mactra veneriformis     polysaccharide     monosaccharide composition     oral glucose tolerance test    

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Enhanced triallyl isocyanurate (TAIC) degradation through application of an O

Yapeng Song, Hui Gong, Jianbing Wang, Fengmin Chang, Kaijun Wang

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 4, doi: 10.1007/s11783-020-1243-z

Abstract: Abstract • UV/O3 process had higher TAIC mineralization rate than O3 process. • Four possible degradation pathways were proposed during TAIC degradation. • pH impacted oxidation processes with pH of 9 achieving maximum efficiency. • CO32– negatively impacted TAIC degradation while HCO3– not. • Cl– can be radicals scavenger only at high concentration (over 500 mg/L Cl–). Triallyl isocyanurate (TAIC, C12H15N3O3) has featured in wastewater treatment as a refractory organic compound due to the significant production capability and negative environmental impact. TAIC degradation was enhanced when an ozone(O3)/ultraviolet(UV) process was applied compared with the application of an independent O3 process. Although 99% of TAIC could be degraded in 5 min during both processes, the O3/UV process had a 70%mineralization rate that was much higher than that of the independent O3 process (9%) in 30 min. Four possible degradation pathways were proposed based on the organic compounds of intermediate products identified during TAIC degradation through the application of independent O3 and O3/UV processes. pH impacted both the direct and indirect oxidation processes. Acidic and alkaline conditions preferred direct and indirect reactions respectively, with a pH of 9 achieving maximum Total Organic Carbon (TOC) removal. Both CO32– and HCO3– decreased TOC removal, however only CO32– negatively impacted TAIC degradation. Effects of Cl– as a radical scavenger became more marked only at high concentrations (over 500 mg/L Cl–). Particulate and suspended matter could hinder the transmission of ultraviolet light and reduce the production of HO· accordingly.

Keywords： Triallyl isocyanurate     O3/UV     Advanced oxidation processes (AOP)     Degradation pathway    

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Experiment and calculation on seismic behavior of RC composite core walls with concealed steel truss

Wanlin CAO , Weihua CHANG , Changjun ZHAO , Jianwei ZHANG ,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 3,   Pages 255-261 doi: 10.1007/s11709-009-0043-0

Abstract: To improve the seismic performance of reinforced concrete core walls, reinforced concrete composite core walls with concealed steel truss were proposed and systemically investigated. Two 1/6 scale core wall specimens, including a normal reinforced concrete core wall and a reinforced concrete composite core wall with concealed steel truss, were designed. The experimental study on seismic performance under cyclic loading was carried out. The load-carrying capacity, stiffness, ductility, hysteretic behavior and energy dissipation of the core walls were discussed. The test results showed that the seismic performance of core walls is improved greatly by the concealed steel truss. The calculated results were found to agree well with the actual measured ones.

Keywords： reinforced concrete     steel truss     core walls     seismic performance    

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Effective degradation of tetracycline by mesoporous Bi

Xiaolong CHU,Guoqiang SHAN,Chun CHANG,Yu FU,Longfei YUE,Lingyan ZHU

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 2,   Pages 211-218 doi: 10.1007/s11783-014-0753-y

Abstract: Bi WO was synthesized with a hydrothermal method at different pHs and used for the degradation of tetracycline (TC) in water. The mesoporous Bi WO prepared at pH 1 (BWO-1) displayed the highest adsorption and degradation capacity to TC due to its large surface area and more efficient capacity to separate photogenerated electrons and holes. 97% of TC at 20 mg·L was removed by BWO-1 at 0.5 g·L after 120 min irradiation under simulated solar light. Only 31% of the total organic carbon (TOC) was removed after 360 min irradiation although the TC removal reached 100%, suggesting that TC was mainly transformed to intermediate products rather than completely mineralized. The intermediates were identified by high-performance liquid chromatography-time of flight-mass spectrometry (HPLC-TOF-MS) and possible photodegradation pathways were proposed.

Keywords： Bi2WO6     hydrothermal synthesis     tetracycline (TC)     photocatalysis    

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Hydrophilic/underwater superoleophobic graphene oxide membrane intercalated by TiO

Zhichao Wu, Chang Zhang, Kaiming Peng, Qiaoying Wang, Zhiwei Wang

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 3, doi: 10.1007/s11783-018-1042-y

Abstract: Membrane technology for oil/water separation has received increasing attention in recent years. In this study, the hydrophilic/underwater superoleophobic membrane with enhanced water permeability and antifouling ability were fabricated by synergistically assembling graphene oxide(GO) nanosheets and titanium dioxide (TiO ) nanotubes for oil/water separation. GO/TiO membrane exhibits hydrophilic and underwater superoleophobic properties with water contact angle of 62° and under water oil contact angle of 162.8°. GO/TiO membrane shows greater water permeability with the water flux up to 531 L/(m ·h·bar), which was more than 5 times that of the pristine GO membrane. Moreover, GO/TiO membrane had excellent oil/water separation efficiency and anti-oil-fouling capability, as oil residual in filtrate after separation was below 5 mg/L and flux recovery ratios were over 80%.The results indicate that the intercalation of TiO nanotubes into adjacent GO nanosheets enlarged the channel structure and modified surface topography of the obtained GO/TiO membranes, which improved the hydrophilicity, permeability and anti-oil-fouling ability of the membranes, enlightening the great prospects of GO/TiO membrane in oil-water treatment.

Keywords： Hydrophilic     Superoleophobic     Graphene oxide     Membrane     Titanium dioxide nanotubes     Oil-water separation    

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Title Author Date Type Operation

Management innovation of Chang’e-5 project

Journal Article

Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

Journal Article

Using heterogeneous patent network features to rank and discover influential inventors

Yong-ping DU,Chang-qing YAO,Nan LI

Journal Article

Implications of astrocytes in neurovascular coupling

You ZHOU MD, Chang-Kai SUN MD,

Journal Article

Templated synthesis of urchin-like zinc oxide particles by micro-combustion

Xintong ZHOU, Quan ZHANG, Chang-jun LIU

Journal Article

Effect of different gas releasing methods on anaerobic fermentative hydrogen production in batch cultures

Sheng CHANG, Jianzheng LI, Feng LIU, Ze YU

Journal Article

Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Journal Article

Preparation and characterization of a novel microorganism embedding material for simultaneous nitrification and denitrification

Ming Zeng, Ping Li, Nan Wu, Xiaofang Li, Chang Wang

Journal Article

Erratum to: Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

Journal Article

Strategic Thinking on a Revolution/an Evolution in Production and Consumption of Energy in China

Ke-chang Xie,Ke Liu

Journal Article

Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis

Lingchong WANG, Hao WU, Nian CHANG, Kun ZHANG

Journal Article

Enhanced triallyl isocyanurate (TAIC) degradation through application of an O

Yapeng Song, Hui Gong, Jianbing Wang, Fengmin Chang, Kaijun Wang

Journal Article

Experiment and calculation on seismic behavior of RC composite core walls with concealed steel truss

Wanlin CAO , Weihua CHANG , Changjun ZHAO , Jianwei ZHANG ,

Journal Article

Effective degradation of tetracycline by mesoporous Bi

Xiaolong CHU,Guoqiang SHAN,Chun CHANG,Yu FU,Longfei YUE,Lingyan ZHU

Journal Article

Hydrophilic/underwater superoleophobic graphene oxide membrane intercalated by TiO

Zhichao Wu, Chang Zhang, Kaiming Peng, Qiaoying Wang, Zhiwei Wang

Journal Article