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CDK 1

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PROTAC 1

ParaSol 1

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Therapeutic effect of medical glue combined with the great omentum in severe tunica muscularis injury

REN Peitu, LU Baochun, RUAN Xinxian, CHEN Zhiliang, MA Yuliang, FU Hong

Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 143-146 doi: 10.1007/s11684-008-0027-9

Abstract: The patients with severe tunica muscularis injury were treated by medical glue combined with the greaterTherefore, reasonable use of medical glue combined with the greater omentum can not only improve the

Keywords： abscess initial muscularis anastomotic medical

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

Keywords： PROTAC molecular glue degrader cell cycle CDK cyclin

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A Comparison of SWAT Model Calibration Techniquesfor Hydrological Modeling in the Ganga River Watershed

Nikita Shivhare, Prabhat Kumar Singh Dikshit, Shyam Bihari

Engineering 2018, Volume 4, Issue 5, Pages 643-652 doi: 10.1016/j.eng.2018.08.012

Abstract: sequential uncertainty fitting version 2 (SUFI-2), the generalized likelihood uncertainty estimation (GLUEModels utilizing SUFI-2, GLUE, and ParaSol methods were constructed, and these algorithms were compared

Keywords： Remote sensing Geographic information system Soil and Water Assessment Tool Hydrological modeling SUFI-2 GLUE