Search scope:
排序： Display mode:
Progress of Pharmaceutical Continuous Crystallization Review
Dejiang Zhang, Shijie Xu, Shichao Du, Jingkang Wang, Junbo Gong
Engineering 2017, Volume 3, Issue 3, Pages 354-364 doi: 10.1016/J.ENG.2017.03.023
Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared.
Keywords： Continuous crystallization Pharmaceutical MSMPR Tubular crystallizer Control strategy
Title Author Date Type Operation
京公网安备 11010502051620号
