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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese
Wei Wang,Ming Li,Li Wang,Xueqing Yu
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 507-516 doi: 10.1007/s11684-016-0475-6
Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibility. This study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibility and clinical manifestations of patients with IgAN in southern Han Chinese. A PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229 healthy subjects. Clinical data were collected from each patient at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects. High frequency of HLA-DQB1*060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy controls. Further stratification analysis revealed that the frequency of DQB1*060101 was significantly higher in patients with urine protein≥1.0 g/24 h than in patients with urine protein<1.0 g/24 h. In combination with our previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of HLA-DRB1*070101-DQB1*020101 was significantly lower (OR= 0.194, Pc = 0.016) compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility in Chinese Han population.
Keywords: DQB1 human leukocyte antigen (HLA) IgA nephropathy haplotype association study
The Decarbonization of Construction—How Can Alkali-Activated Materials Contribute?
John L. Provis,Susan A. Bernal,Zuhua Zhang,
Engineering doi: 10.1016/j.eng.2023.09.014
Does environmental infrastructure investment contribute to emissions reduction? A case of China
Xiaoqian SONG, Yong GENG, Ke LI, Xi ZHANG, Fei WU, Hengyu PAN, Yiqing ZHANG
Frontiers in Energy 2020, Volume 14, Issue 1, Pages 57-70 doi: 10.1007/s11708-019-0654-7
Keywords: environmental infrastructure investment (EII) CO2 emission SO2 emission PM2.5 pollution stochastic impact by regression on population affluence and technology (STIRPAT) model governance
ZHAO Peng, ZHU Tong, LIANG Baosheng, HU Min, KANG Ling, GONG Jicheng
Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 2, Pages 159-165 doi: 10.1007/s11783-007-0028-y
Keywords: diameter atmosphere suburban contribute agricultural
Coal to gas single cell protein-contribute to resolving the food crisis of China in future
Cao Chen,Yu Bo and Gu Weidong
Strategic Study of CAE 2015, Volume 17, Issue 3, Pages 107-112
Keywords: urbanization; food crisis; non-grid wind power; coal-to-gas; single cell protein
Title Author Date Type Operation
DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese
Wei Wang,Ming Li,Li Wang,Xueqing Yu
Journal Article
The Decarbonization of Construction—How Can Alkali-Activated Materials Contribute?
John L. Provis,Susan A. Bernal,Zuhua Zhang,
Journal Article
Does environmental infrastructure investment contribute to emissions reduction? A case of China
Xiaoqian SONG, Yong GENG, Ke LI, Xi ZHANG, Fei WU, Hengyu PAN, Yiqing ZHANG
Journal Article
Characteristics of mass distributions of aerosol particle and its inorganic water-soluble ions in summer over a suburb farmland in Beijing
ZHAO Peng, ZHU Tong, LIANG Baosheng, HU Min, KANG Ling, GONG Jicheng
Journal Article