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The development and benefits of metformin in various diseases

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 388-431 doi: 10.1007/s11684-023-0998-6

Abstract: Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety,Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metforminMeanwhile, many novel targets of metformin have been gradually discovered.Herein, we summarized the benefits of metformin in four types of diseases, including metabolic associatedAlthough there have been countless studies of metformin, longitudinal research in each field is still

Keywords： metformin metabolism cancer aging neurological disorder

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Antioxidative potential of metformin: Possible protective mechanism against generating OH radicals

Huibin Guo, Ning Wang, Xiang Li

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 2, doi: 10.1007/s11783-020-1313-2

Abstract: Abstract • Metformin consumes O2−• and OH• induced by PM are proposed. • OH• dominated the oxidationof metformin compared with O2−• • Metformin can prevent the harm of ROS induced by PM to human health. • Antioxidative potential of metformin was first proposed to provide measures.reaction mechanism of metformin was analyzed by the density functional theory (DFT) method.Moreover, the OH radical content decreased as the metformin concentration increased.

Keywords： Antioxidative potential Metformin Mechanism OH radical Health protection.

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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract:

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), servingas the main mechanism by which metformin improves hyperglycemia of T2D.Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis.These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty

Keywords： metformin diabetes hepatic steatosis inflammatory response insulin resistance