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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 541-550 doi: 10.1007/s11684-020-0780-y

Abstract: This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc.

Keywords： synthetic lethality     undruggable     transcription factor     c-Myc    

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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Journal Article