This paper first briefly explains the booming era of "New Internet + Big Data + Artificial Intelligence +", then discussed that an intelligent manufacturing system guided by a new-generation of artificial intelligence technology is a new intelligent interconnected manufacturing system that integrates human, machine, material, environment, and information through "New Internet + New Intelligent Manufacturing Resources/Capabilities/Products". This paper also explains the connotation, architecture, and technical system of the intelligent manufacturing system guided by a new-generation of artificial intelligence technology, and introduces the preliminary study on its prototype—big data intelligence in the CASICloud. Finally, some suggestions for developing the intelligent manufacturing system guided by a new-generation of artificial intelligence technology are put forward. Particularly, importance must be attached to the coordinated development of technologies, application, and industries; while highlighting the characteristics of different countries, industries, and enterprises, cooperation and exchange with the whole country or even the whole world must be strengthened, thereby forming a new mode, new means, and new form of intelligent manufacturing in the new era.