Driven by market demands and the artificial intelligent technology, mass customization is emerging. It thus becomes significant to analyze the influence of artificial intelligent technology on the development trend of the mass customization service mode and to summarize the breakthroughs of key technologies that need to be made in the future. Through case studies and expert interviews on furniture, household appliances, clothing and automobile industries, this paper analyzes the development trends of multiple key technologies such as multi-source cross-media heterogeneous database construction, a big-data-based design requirement feature mining system, a virtual experience system and virtual manufacturing, and whole-process information automatic collection, according to various market demands. Suggestions are proposed for popularizing the mass customization service mode integrated with artificial intelligent technology from aspects of top-level design, enterprise, talent and finance.