As the two largest “granaries” in China, the Northeast and Huang-Huai-Hai Plains are the main agricultural producing areas in North China, and the soil environmental risk management and control of these areas are vital to the national food security supply lifeline. This study analyzed the soil heavy metal pollution risks of main agricultural producing areas in North China by the potential ecological risk index method. The high-risk areas of Cd pollution are mainly distributed in Shenyang City in the east of Liaohe Plain, Jinzhou City and Huludao City in the south of Liaohe Plain, Shuangyashan in the Sanjiang Plain, Tianjin City in the Haihe Plain, and Xinxiang City in the southwest of the yellow river flood plain; Hg pollution high-risk areas are mainly distributed in Beijing and Tianjin of the Haihe Plain, and around the Shenyang City of the Liaohe Plain. The chemical industry, followed by the livestock and poultry industry, as well as the metal smelting and processing industry, is the major potential source of heavy metal pollution of soil in the Northeast and Huang-Huai-Hai Plains. This study proposed the “one area, one policy” pollution prevention strategy and key environmental protection projects from the aspects of environment monitoring and warning of agricultural products producing areas, clean production of industrial and mining enterprises, and comprehensive treatment of livestock and poultry pollution, which is based on local conditions and classification guidance. This study can provide important references for the strategic planning of sustainable development of the ecological environment of major agricultural producing areas in North China.