Information application plays an inclusive and fundamental role in exchanges and cooperation between countries along the Belt and Road, and offers a new perspective for the joint development of information infrastructure. This paper first analyzes the difficulties that China met when participating in the information infrastructure construction in countries along the route and depicts the emergence and development of information application service enterprises in countries along the route. Research shows that information infrastructure construction in countries along the route is slow, due to complex geopolitical, ideological, and national security factors. Information application is an emerging field with adequate market competition. It accords with the needs for social life and government governance, so the cooperation space in this field is huge. Using basic information application to activate the information infrastructure construction of countries along the route is an effective way to achieve connectivity.