To grasp the major contradictions of China’s regional food security in the new era is the precondition for ensuring national food security. This paper introduces the current situation and the major challenges of China's regional food security, analyzes the change trend of supply and demand and development potentials for regional food security, and presents corresponding strategic visions for future development. Furthermore, it proposed several policy suggestions for ensuring China's regional food security, including implementing the dual responsibilities of food security assurance and environment protection by governments at all levels, rationally planning major special funds for regions, fostering novel business entities, and promoting modern agriculture by improving its quality.