Both energy security and climate change are key challenges for China in the New Era. Northwest China, especially the Energy Golden Triangle area and Xinjiang, is playing a significant role in China’s energy supply owing to its rich energy resources. However, protecting the vulnerable ecosystems in this region becomes increasingly challenging; therefore, developing a performance improvement plan for energy revolution becomes urgent in this region. In this article, we first analyze the unique competencies and challenges regarding resource, industry, and location; considering the requirements of energy revolution, we propose that the Northwest China should be established as a national multi-energy integration technology demonstration base, a national coal-to-fuel strategic reserve base, and a national comprehensive energy supply base. As a strategic path for promoting energy revolution in Northwest China, multi-energy integration consists of three main themes and six demonstration measures. The three main themes are the clean and efficient use of fossil resources and coupling substitution, multi-energy complementarity and large-scale application of renewable energy, and the low-carbon and intelligent multi-energy integration. Adopting these measures, a Northwest China approach to energy revolution can be formed that is characterized by multi-power integration and led by energy technology revolution.