The industrial Internet security industry is crucial for the healthy development of industrial Internet. The layout of this industry in developed countries and regions is relatively perfect. To strengthen the manufacturing, cyberspace, and digital sectors, the layout of this industry in China needs to be optimized. This study investigates the development demands for the industrial Internet security industry using literature research and intelligence analysis. Subsequently, the current status of industrial Internet security industry layout in the United States, Germany, the United Kingdom, Japan, and other developed countries is studied from the aspects of policy guidance, enterprise innovation, collaborative development, capital integration, and alliance ecology. Based on this, the international development trend is analyzed. Meanwhile, the current status and challenges faced by China are discussed in terms of policy and standard, technology and product, market space, investment and financing, and regional layout. The study points out that the optimization of China’s industrial Internet security industry layout should draw on the useful experience of other countries and consider China’s development reality. It is suggested that China should maximize the advantages of its system and mechanism to coordinate the development of the security industry; adhere to independent innovation to create an internationally competitive brand; improve the security standards system to actively lead the international rule making; strengthen the policy and financial support for small- and medium-sized enterprises to stimulate their innovation vitality; and build a collaborative development ecology to create an international and domestic dual circulation development pattern.