Novel research and development (R&D) institutions in life sciences and medicine are the products of the latest round of technological revolution and industrial transformation. Under these new historical circumstances, accelerating the transformation of achievements from these novel R&D institutions is of strategic significance for cultivating national technological strength in the field of biomedicine, strengthening China's biopharmaceutical industry, and achieving self-reliance in biomedical science and technology. This study presents the new dynamic of achievement transformation in novel R&D institutions in life sciences and medicine, conducts an in-depth analysis of related experience from both China and abroad through a literature review and field investigation, and summarizes four operational transformation modes of these institutions. Focusing on the "core-catalyst" system of achievement transformation in these novel R&D institutions, we research the achievement transformation mechanism system that adheres to the principles of innovation and market rules, and propose a micro-ecological model for achievement transformation mechanisms in these novel R&D institutions, including three core systems (i.e., technology R&D, technology implementation, and investment systems) and a government macro-support catalytic system. Policy recommendations are offered with an emphasis on top-level design, creating an innovative ecosystem, activating transformation dynamics, and strengthening system support, to provide theoretical and practical references for accelerating the transformation of achievements from Chinese novel R&D institutions in life sciences and medicine.