Currently, global technological innovation is unprecedentedly intensive and active, and the forms of technology and industry are undergoing systematic changes. Disruptive and systemic innovations in engineering science and technology have become the focus of strategic competition. Based on the development demand for engineering science and technology in China and the world trends of engineering science and technology development, this study proposes a strategic research method system that consists of economic forecasting, demand analysis, technology foresight, vision analysis, strategic architecture, technology roadmap, and policy selection. The study also predicts the economic and social development trends in China by 2040 and depicts nine visions of Chinese society in 2040. Based on the strategic research on the development of engineering science and technology in major fields, an overall strategic concept of engineering science and technology development is proposed centering on the nine visions, which involves promoting information technologies, reshaping the energy system, innovating industrial science and technologies, constructing the future cities, developing the blue economy, revitalizing agriculture and the rural areas, safeguarding the health of all the people, building a beautiful China, and constructing a safe China. An overall two-stage roadmap for engineering science and technology development between now and 2040 is also proposed. At the first stage, it is necessary to strengthen the industrial foundation and chain, achieve international leadership in major fields of engineering science and technology, and develop new areas and technologies with core competitiveness. At the second stage, it is suggested to focus on security, resilience, and original innovation and build a new technological ecosystem.