China's deep-seated strategic mineral resources are sparsely distributed and heavily reliant on imports from abroad. Promoting the coordinated exploitation of multi-type mineral resources in deep strata is significant for safeguarding national energy and resource security. This study focuses on pathways for multi-resource synergistic development, employing an integrated methodology that combines comprehensive analysis, multi-objective spatial optimization, and case studies in representative regions. It analyzes the spatial distribution characteristics of six critical mineral resources: lithium salts, potassium salts, helium, sandstone-type uranium, rubidium salts, and strontium salts, and explores their coupled exploitation mechanisms with oil/gas and geothermal resource. Strategic advantages and technical challenges for deep mineral resource synergistic mining in China are identified. This study incorporates multi-resource symbiotic relationships into mining sequence decision-making frameworks. A two-dimensional optimization methodology integrating "spatiotemporal alignment" and "efficiency synergy" is developed to overcome limitations of conventional single-resource exploitation paradigms. Through multi-source collaborative three-dimensional exploration, multi-dimensional comprehensive evaluation, and two-dimensional coordinated development, the implementation path of prioritized layout in resource-rich areas and coordinated development of industrial chains is clarified. Specific scenarios for collaborative mining of oil, gas, geothermal, and multi-type minerals are creatively constructed, and technical routes are formulated to improve the resource utilization rate and reduce mining costs under different scenarios. Demonstration projects and industrialization potentials are defined, and a strategic layout for the centralized, coordinated, and orderly development of industrial chains is formed. This study provides actionable theoretical support and practical models for the integrated development of deep mineral resources.