Lunar helium-3 is regarded as a key strategic resource for future fusion energy and advanced cryogenic technologies, and it is of great significance for sustainable energy development and future deep-space exploration. Although helium-3 is enriched in fine-grained lunar regolith, its practical exploitation is still constrained by resource detection under extreme lunar environments, high energy consumption of extraction processes, and requirements for closed-loop storage and transportation. Therefore, an engineering-oriented application system for lunar helium-3 utilization is urgently needed. Oriented toward the full-chain development requirements of lunar helium-3, this study reviews the current research status and planned exploration missions related to lunar helium-3, and analyzes the source as well as implantation and occurrence mechanisms of lunar helium-3, together with resource assessment methods including remote-sensing inversion and in-situ mass spectrometric detection. Moreover, it examines the energy-efficiency constraints and engineering difficulties in collection and extraction processes, including high-temperature thermal release, mechanical crushing, and coupled thermal extraction methods. Key technical chains, including gas enrichment, packaging, cryogenic storage, and Earth-Moon transportation, are further discussed from a systems engineering perspective. On this basis, a technological evolution route of "ground-based development, in-situ verification, and stepwise scale-up" is proposed. Future research should focus on high-resolution in-situ detection of lunar helium-3, low-energy thermal release, and deep-cryogenic staged separation; and multi-source data fusion inversion, coupling with in-situ energy utilization, and integrated design of modular collection and extraction systems should be strengthened. This study presents the evolutionary logic of lunar helium-3 resource development from laboratory simulation to lunar-surface engineering practice, which may provide a reference for future technological research and engineering implementation in this field.