Sutong Bridge, as a worldrecord cablestayed bridge with its main span exceeding 1 000 m constructed in Yangtze River estuary region in China, is located at a site with complicated hydrologic conditions and poor geotechnical conditions and therefore, scour protection will be a decisive factor for ensuring smooth and successful construction of this bridge. This paper, starting from structural description of deepwater group pile foundation, analyzes impact to the bridge safety introduced by scour and its protection and further presents different solutions of scour protection for foundation structures of this bridge.