The research on biomaterials has gotten achievements during the past 30 years. However, few kinds of them are well accepted clinically. Even those implanted in vivo for long time are considered to be exotic things by bodies. It prompts people to design biomaterials through biomimetic approaches. This paper overviews the design of artificial extracellular matrixes and the control of apoptosis based on the interaction between biomaterials and protein, saccharide and DNA. In view of the broadness and flexibility life science, it is recommended to design the biomaterials on cellular and molecular levels to enhance the affinity of biomaterials and host, and to promote the development of intelligent and environment-friendshiply biomaterials.