The paper introduces the contemporary system of science & technology and meta-synthesis established by Academician Qian Xuesen, The contemporary system of science and technology has a matrix structure which has eleven department of science and technology laterally and three hierarchies, i.e. fundamental theory, technical science and application technology longitudinally. The meta-synthetic is a methodology that consist of meta-synthetic engineering and hall for workshop of meta-synthetic engineering. The paper also discusses their applications in practice.