This paper analyzes macro situation of petroleum economy safety home and abroad, and ten latent factors impacting on it. Four new characters of petroleum economy safety and the advanced theory of basing safety on development are presented. With the theory of complexity science, this paper demonstrates the complexity of the system of petroleum economy safety, and the basic thought of opportunity-cybernetics is brought forward. Five integrated and compositive indexes for petroleum safety are chosen and the upper and lower limit for them are confirmed. With scientific index system and evaluation system set up here, applied software of database system and monitor-warning system for petroleum economy safety is programmed. This software can save time and cost for safety decision drastically.