In this paper, the concepts of rough sets are used to define equivalence classes encoding input data sets, and eliminate redundant or insignificant attributes in data sets so that to reduce the complexity of system construction. In order to deal with ill-defined or real experimental data, an input object is represented as a fuzzy variable by fuzzy membership function, and the significant factor of the input feature corresponding to output pattern classification is incorporated to constitute a fuzzy inference so that to enhance nonlinear mapping classification. A new kind of rough fuzzy neural classifier and a learning algorithm with LSE are proposed in this paper. A integration of the merits of fuzzy and neural network technologies can not only accommodate overlapping classification and therefore increase the performance of nonlinear mapping classification, but ensure more efficiently to handle real life ambiguous and changing situations and to achieve tractability, robustness, and low-cost solutions.