In recent years, Cellular Automata (CA) micro-simulation has emerged as an effective technique for modeling traffic flow and achieved a lot of success. But the human movement and occupant evacuation are much more complex than traffic flow. It is necessary for us to consider more human behavior characteristics if try to apply the model in practice. For the advantages of agent in simulating human intelligence, a multi-agent model based on CA is presented which focuses on simulating the human behavior and the effect on human by building structure. In the model, people are represented by agents and they move over the network which is represented by a lattice of cells. Agents can perceive the local environment and chcx)se their moving direction autonomously. In order to simulate human movement in very complex structure building the acquainting and evacuating states based on the ideas of artificial life are introduced and that is proved successful in simulation. Using this model the effect of the building structure on human behavior can be studied and the performance of building design can be assessed.