For accomplishing the need of S-band satellite tracking, telemetry and control (TT & C) drilling, the simulation system is put forward. Firstly, according to the characteristics of space TT & C system and S-band TT&C equipments, composing and function of the simulation system are defined. The main part of the simulation system is described in detail. Secondly, those of the simulation system, such as the work mode, the main technique specification, the interface regulation, are confirmed. Finally, combining with the actual application, the simulation system that based on hardware-in-the-loop mathematics model is proved to reach equipollence on data layer by contrast to engineering satellite. At the same time, the development tendency of TT&C simulation system is prospected.