China is facing challenge of food safety due to that the food consumption for the whole society turns its focus on food quality and safety, while developing economy. This paper, from the angle of developing national food safety strategy and strengthening food safety science and technology, puts forward four priorities for the food safety in China: Firstly, risk analysis is the scientific basis of food safety, and risk assessment is the key technology of food safety, it is suggested to be the first priority of food safety strategy. Secondly, “from farm to table” comprehensive control system is the theoretical basis of food safety technology and practice all along the food chain, which provides the technical assistance for surveillance of food safety. Thirdly, inspection and monitoring technology is the support blocks of alerting, prevention and emergence response, emphasized effort should be taken to exploit a series of rapid detection technology and standardized detection technology for on-line control and lab inspection. Fourthly, the management conception with government, producers and consumers as responsible bodies is the basic principle of food safety, all responsible parties should bear the responsibility for food quality and safety.