The airliner cabin air quality is related to the safety, health and comfort of passengers and cabin crew. Considering the unique cabin environment, a new cabin air purifier system based on nanophotocatalytic oxidation is described. A detailed performance comparison has been made between the photocatalytic oxidation reactor and the carbon adsorption/high efficiency particulate arresting filters for airliner cabin. The life-cycle costs for carbon adsorption/high efficiency particulate arresting filters are significantly higher than that for photocatalytic oxidation reactor. It also indicates that photocatalytic oxidation reactor can not only control the level of volatile organic compounds but also purify airborne bioaersols. These characteristics can help to decrease the replenishment of fresh air, save the power and reduce airliner cost.