To investigate the molecular mechanism for phlegm-dampness constitution,examining the genome DNA of peripheral blood cells of six phlegm-dampness constitution and six normal constitution by using Affymetrix GeneChip Mapping 500K Array.We had identified 442 genes with significant differences between the phlegm-dampness constitution and the normal constitution by using Affymetrix Gene Chip Human Genome U133 plus-2, base on research results of prophase, sieve the related gene and characteristics of single nucleotide polymorphisms( SNP) of phlegm-dampnessconstitution.5 related genes and 6 SNPs with significant differences were identified between the phlegm-dampness constitution and the normal constitution. Further biologianalysis on the genes identified between two constitution groups demonstrate that they are involved in enzyme activity,sterol transporter activity,participate in the biology process of lipid metabolism, cholesterol metabolic process,brown fat cell differentiation, gluconeogenesis and thermoregulation.These results indicate that the Molecular characteristic of phlegm-dampness constitution is related to metabolism disorder.