Even in the science-technology highly developed time, diseases are changing incessantly with the development of society. A number of new and vicious types of diseases emerged uninterruptedly. The diseases changed on infinite variety of forms, even more these diseases are all dangerous. Under this situation living environment of human being is facing damages, and medicine science is meeting by rigorous challenges. Authors suggested that all diseases were composed with several special basic symptoms, the cause of symptoms was unbalance of five-organs and their functions. The function consists of tissues, organs and systems of human body, which formatted an organic system. It was discovered that the function of five-organs kept almost constantly in a considerably period of time, the way human being reacts to diseases was invariant. That means symptoms did not change with the variant of the diseases. Basing on these facts, and abstracts from "Huangdi Nei Jing" , "Yi Jing"  and "Dao De Jing" , authors formatted the general principal of all kinds of Diseases (GPD) theory, which extended the traditions Chinese medical (TCM) theory in a new field.