Based on engineering practice in Beijing-Shanghai high speed railway, effect to concrete workability, meachincal performance, and durability of mineral admixtures are studied, at the same time the preparing technology of high performance concrete with high-volume supplemementary cementitious materials are studied. Combining with pracitce engineering, control technology of raw materials, design of mixing proporation and construction for high performance concrete with high-volume supplemementary cementitious materials are introduced.