The engineering management of medical emergent rescue in severe natural disaster was discussed following Chinese Wenchuan Earthquake. It is illustrated that the medical rescue is much more important and difficult in such a severe sudden incident. The great achievement and problems of the medical rescue in Wenchuan Earthquake were discussed in detail. On the basis of these discussions, the thinking and suggestions for enhancement of medical rescue in the level of macro policy, medicine and health, as well as education and training were given in these papers.