The development of Ni-based alloy BG2250 tubing used in severe sour gas field is introduced in this paper. With great efforts in analysing imported similar products, and researching the techniques,such as composition optimization, AOD melting, electro-slag remelting, forging, extrusion, cold rolling, premium thread connection designing and machining, and corrosion evaluation, etc.,the mechanical properties, corrosion resistance and pipe qualities of the Ni-based alloy tubing developed by Baosteel, such as BG2250-125, has reached advanced level compared with other international pipe companies. The Ni-based alloy tubing BG2250-125 has been successfully applied to Puguang gas well, which provides significant guarantee for the severe sour gas field exploration in China.