The risk of ship collision to the center tower located at the edge of navigation channel of Taizhou Yangtse River Highway Bridge is expected. To protect the bridge, this research integrates a variety of factors to study the protection system of the center tower. Aiming at the suspension bridge with three-tower-span, with combination of ship navigation planning, bridge parameters and characteristics of bridge foundation, the ship collision research is carried out and protective measure scheme is proposed. Calculation and analysis for crash characteristics are carried out to determine the technical and economic characteristics of the protective measures. The safety of the bridge and effectiveness of the protection system under ship collision is studied by applying the dynamic FEM techniques.