Since 1980's, a lot of long-span prestressed concrete continuous system bridges have been constructed in China, and great success has been achieved. However, with the increase of numbers and service life of bridges, some similar diseases have been showed in this kind of bridges in succession. In this paper, the forms of many typical faults like excessive deflection in the mid-span, box beam crack and bottom slab stripping in the closure segment of mid-span, etc., have been summarized. And the characteristics of these faults' happening time, trend of development and distribution form have been pointed out. Their causes and corresponding prevention countermeasures have been analyzed. At last the direction which needs further study about the theory of computation and the measures which should be taken in design have been figured out .