Taizhou Bridge is a highway triple-tower and double-span bridge with span arrangement of 1 080 m+1 080 m, the middle tower is located in the center of Yangtze River. Several proposals are studied for the foundation type of the middle tower, especially the comparison between caisson foundation and bored pile foundation with higher pile cape. The caisson foundation is adopted because of its concise structural behavior, larger rigidity and simpler construction procedure, and it's far more economic. According to the configuration requirement of the first section and the structural force, the cross-section of the adopted rectangle caisson's dimension is 58 m×44 m with four circle chambers at corners, the total depth of the caisson is 76 m. The bottom segment of the caisson adopts concrete caisson with steel hull, and its upper segment adopts reinforced concrete structure. The structural arrangement, construction method, comparison of the project's proposal and the design feature are introduced in the paper. The design of the caisson foundation will provided good experience for the future similar projects.