Ordos Basin is a sedimentary basin with the fastest oil and nature gas production growth rate in China in recent 10 years and has become the second largest oil and gas production basin and the largest nature gas production region. The history of oil and nature gas exploration and development in Ordos Basin was reviewed. Important knowledge, main technology, development management model ,oil-nature gas production and economic and social benefits achieved in Ordos Basin development were summarized. Based on development planning ,oil-gas resources, unconventional hydrocarbon resources and other resources, development prospect of Ordos Basin was discussed and several suggestions on sustainable development of Ordos Basin were proposed.