As a resource integration mine, there were many problems in Tangshangou Mine such as complex ventilation system and much hidden danger. By determining the ventilation resistance and fan performance test and reasonable evaluation of mine ventilation system, the problems of original mine ventilation system were found out and analyzed, and an optimizing and transforming scheme for ventilation system was proposed. The results showed that the resistance of mine ventilation system was reduced and the stability and ability of fighting against natural calamities of mine ventilation network were improved.