The characteristics and the present situation of significant construction project technological innovation are analyzed in this paper. The core problem restricting significant construction project technological innovation is dissected. The basic framework of significant construction project-oriented technological innovation network is set up. Then the starting point, evolution path and integration method are analyzed. And the dynamic mechanism, the collaborative mechanism and the learning mechanism are discussed,which can provide useful theoretic reference to establish the new inter-organization coordinated technological innovation mode, and to improve the technological innovation efficiency of significant construction project.