Evident change in climate of the Qinghai-Tibet Plateau occurred in the past half century. Surface air temperature significantly increased, and annual and summer precipitation rose in most parts of the plateau. The change in climate has in some extent affected the human and natural systems. Expected warming in the coming decades will have complicated impacts on glacial, frozen ground, hydro-cycle, ecosystems, agricultural production, energy climatic resources, transportation, hydro-engineering projects and inhabitant environment. It is therefore necessary, in such areas as the construction of large engineering projects, to plan for cost-benefit adaptation to climate change. A framework of adaptation measures for different fields of engineering construction is discussed in this paper.