In order to ensure the sustainable development of Shanghai Port and the economical and social development of Yangtze River Delta and Yangtze River Basin, this paper proposes and demonstrates the technological possibility of the port site on Hengsha shoal, analyzes the preliminary layout of the port by the numerical simulation model, and estimates the sedimentation intensity by means of various methods. The conclusion indicates that the port site of Hengsha shoal is possible and feasible.