The Fourth Nanjing Yangtze River Bridge is the first suspension bridge of three-span steel box girder using continuity and flexible bearing system with a main span of 1418 m, and makes use of the flexible bearing system and distributional force transmission system with main rope for the first time. It overcomes the deep foundation design and construction technical problems of oversized "∞" shape diaphragm wall and ultra-large well-sinking under complicated geological conditions, proposes the technologies of main rope mixed-knit and argon-rich gas shielded arc welding, and uses the pavement technique of compound gussasphalt at steel bridge deck. Additionally, it utilizes synthetical technique to control construction quality of bulk mass concrete. This text summarizes the construction management and key technical innovation.