Reasonable rock-explosive matching is of great important to the enhancing of explosive energy effective utilization and the improving of rock fragmentation effect. The traditionally emphasized method of acoustic impedance matching is not reasonable. Starting from the blasting breakage mechanism, a new method of rock-explosive matching in drilling and blasting is proposed. The new approach chooses explosive parameters by reasonable control of the size of crushed zone under the condition of fully fragmentation between adjacent balstholes. This method can intuitively reflect the blasting fragmentation effect and energy effective utilization, which is easy to implement. Also, a modified model is developed, with the combination of adjacent blastholes explosion load taken into account. As a result, explosive parameters for different grades of rock are given in full coupling on-site mixed explosive charge under different project objectives.