This study is to explore the influence of new three-dimensional and reticular intrauterine device (NTDR-IUD) on animal uterine electromyography and endometrial receptivity as the goal. Three types (short，median and long) of NTDR-IUD were placed into uterus of female white New Zealand rabbits. Conventional surgical incision was performed in the abdominal wall of rabbits，the uterine electromyography (EMG) was carried out by muscular electrophysiological testing. After placing NTDR- IUD，the slow wave frequency and average amplitude were increased. All of rabbits of control group were pregnant，and 5 pregnancies (fetal rabbits were found in the uterus without NTDR-IUD portion) in short group and 2 in median group. No pregnancy was found in the long NTDR-IUD group. The number of pregnant rabbits was signifi-cant difference between control group and the short，median and long of NTDR-IUD group (P=0.000，P=0.033 and P=0.001). The contraceptive effect of NTDR-IUD may be by interfering with uterine EMG，and related with its size and shape.