To provide evidence for effectiveness evaluation of the government project free pre- pregnancy health examination through reporting exposure of potential risk factors of adverse pregnancy outcome and pregnancy rate and the pregnancy outcome of the couples to be pregnant after free pre- pregnancy physical examination in Jingan District，Shanghai. Followups were completed to women who had a free pre-prenancy health examination in Jingan District from August 2011 to November 2012，which foucused on exposure of potential risk factors of adverse pregnancy outcome，time of pregnancy and pregnancy outcome of the women. Chisq test，life table and Logistic regression model were used for data analysis. 1 480 couples had free pre- pregnancy health examinations in the target period. Of which，84.4 % were followed up. By April 2013，48.7 % of the women who were followed up were pregnant. The cumulative pregnancy rate at 3 months and 6 months after free pre-pregnancy health examination was 23.9 % and 45.0 %，respectively. 365 women completed the follow up about pregnancy outcomes.The incidence rate of premature delivery，low birth weight，giant baby and spontaneous abortion was 3.0 %，4.3 %，3.3 % and 6.3 %，respectively. One birth defect was reported during the follow up period，accounting for 0.16% of the number of pregnant women and 0.27 % of the number of women who had pregnancy outcomes. The proportion of husbands who had unhealthy habits such as smoking or drinking ranged from 18 % to 20 %，which was much higher than that of their wives (1 %～3 %). 77 % husbands and 77 % wifives exposed to potential electromagnetic radiation over 8 hours a day. 9 % couples reported exposing to potential teratogenicity such as heavy mental，pesticide and chemical fertilizer in their daily life and work. Over 10 % wivies had exposed to potential teratogenicity after they were pregnant. Primary analysis showed no association between the above factors and adverse pregnancy outcomes. Since the 6-month cumulative pregnancy rate of women who had free pre- pregnancy health examination was lower than 50 %，it is necessary to evaluate the cost benefit of free pre-pregnancy health examination in Shanghai and throughout the country.