To investigate the infective rates of toxoplasma，Rubella virus，cytomegalovirus，herpes simplex virus (TORCH ) in unborn child and pregnant women in Guangzhou City and offer the reference for maternity and child care．We detected the TORCH IgM and IgG from Jan 2013 to December 2013，serum samples from 2 046 women before pregnancy and in the early period of pregnancy in our research institute were tested by ELISA. In the survey of 2 046 women，the total positive rate of TORCH-IgM was 0.88 %，with the higher positive Rates of CMV (0.68 %) and TOX(0.20 %). In the positive Rates of TORCH-IgG，CMV was the highest，up to 97.65 %，followed by RV (85.58 %) and TOXO (4.89 %)．The infective rate of TORCH is pretty high in women before pregnancy and in the early period of pregnancy in Guangzhou，monitor actively and strengthen publicity of TORCH，early detection and early intervention，improving the quality of premarital births and reducing the occurrence of birth defects and disabilities．