To understand the incidence of chromosome breakage rates for the adverse pregnancy history in the infertility couples，we analyzed statistically the chromosomal breakage rates in the infertility couples which have adverse pregnancy history. The results show that：The male patients average age was 29.07，the female patients average age was 28.15，their age and chromosome breakage showed no correlation. The male patients have founded no breakage accounted for 32.38 % of the total in the male patients，the female patients found no chromosome breakage accounted for 37.7 % of the total number of females patients；they have 1 % of breakage rates accounted for 38.11 % of the total in the male cases and the female patients were 34.43 %；they have 2 % of breakage rates which accounted for 21.72 % in total male cases and the female were 23.36 %；they have 3 % of chromosome breakage rates which accounted for 7.79 % in the male cases and the female were 2.87 %；they have 4 %，6 % and 9 % of the chromosome breakage rates that accounted respectively for 0.82 %，0.41 %，0.41 % in total female.The chromosomal breakage rates in the male patients and female no difference (P>0.05).The average chromosome breakage rates were 1.01，their average age was 29.53 and the chromosome breakage rates were 64.96 % in the total cases. The increased rates of chromosomal breakage may be one of the important reasons for embryo damage、miscarriage and other the adverse pregnancy in the infertility couples.