Using 69 paired cases and controls，a 1∶1 matched case control study was carried out in Fujian Maternal and Child Health Hospital. Factors were obtained by field investigation with standardized questionnaires and hair trace element (Sb，Zn，Cu，Fe，Pb，etc.) levels were determined by inductively coupled plasma mass spectrometry (ICP- MS) methods. The SPSS 19.0 Cox proportional hazard model was used to perform risk factors analysis. Results ：The antinomy contents from congenital heart disease (CHD) groups’hairs were significantly higher than that from control group (P=0.000). The larger antinomy content in pregnant women’s hair may expose their babies to a higher risk of CHD (odds ratio(OR)=33.833；95 % confidence interval (CI)：4.060～281.929). Using stainless steel tableware after the first three weeks of pregnancy (OR=8.981，95 % CI：1.085～74.327) and living around 50 m from the road (OR=11.067，95 % CI：1.025～119.521) turn out to be the major risk factors of CHD. The increase of antinomy content in pregnant women’s hair may be a risk factor of CHD.